Nexium
Description
NEXIUM is a type of medicine known as an acid pump inhibitor (also known as a proton pump inhibitor, or PPI). The lining of your stomach contains millions of special cells that produce acid via "acid pumps." It is the job of these pumps to produce the acid that helps in digestion of food.
NEXIUM works by decreasing the acid produced by these acid pumps. NEXIUM turns off (deactivates) some of the pumps to keep acid production under control. By reducing acid production in the stomach, NEXIUM reduces the amount of acid backing up into the esophagus and causing reflux symptoms. But don't worry, you still have enough acid to take care of digestion.
Prolonged acid reflux can, over time, slowly wear away or erode the delicate lining of your esophagus. Only a doctor can determine if you have this damage. NEXIUM can help heal this damage.
Recommendations
NEXIUM is indicated for the short-term treatment (4 to 8 weeks) in the healing and symptomatic resolution of diagnostically confirmed erosive esophagitis. For those patients who have not healed after 4–8 weeks of treatment, an additional 4–8-week course of NEXIUM may be considered. Maintenance of Healing of Erosive Esophagitis.
NEXIUM is indicated to maintain symptom resolution and healing of erosive esophagitis. Controlled studies do not extend beyond 6 months.
NEXIUM is indicated for treatment of heartburn and other symptoms associated with GERD.
In clinical tests, up to 94% of patients were healed with NEXIUM. Your results may vary. Talk to your doctor about prescription NEXIUM.
This drug may be used during pregnancy or nursing only if clearly needed.
Fred, IL, 34:
I have had acid reflux and heartburn for over a year now. Also my stomach hurts after I eat. I have been on tums and other meds but it didn't help. So I got online and your web site came up. I decided to try Nexium. I have been on it two weeks and the second week I noticed I haven't had stomach aches or heartburn. Thanks for the great product!
Phil May, AR, 43:
I received my Nexium this morning. Thank you for all of your e-mails advising me of the status of my order and shipping information. I am very pleased with your company's service and will definitely order from you again.
NEXIUM is indicated for the short-term treatment (4 to 8 weeks) in the
healing and symptomatic resolution of diagnostically confirmed erosive
esophagitis. For those patients who have not healed after 4–8 weeks of
treatment, an additional 4–8-week course of NEXIUM may be considered.
Maintenance of Healing of Erosive Esophagitis.
NEXIUM is indicated to maintain symptom resolution and healing
of erosive esophagitis. Controlled studies do not extend beyond
6 months.
NEXIUM is indicated for treatment of heartburn and other symptoms
associated with GERD.
Precautions
This drug may be used during pregnancy or nursing only if clearly needed.
Fred, IL, 34:
I have had acid reflux and heartburn for over a year now. Also my stomach hurts after I eat. I have been on tums and other meds but it didn't help. So I got online and your web site came up. I decided to try Nexium. I have been on it two weeks and the second week I noticed I haven't had stomach aches or heartburn. Thanks for the great product!
Phil May, AR, 43:
I received my Nexium this morning. Thank you for all of your e-mails advising me of the status of my order and shipping information. I am very pleased with your company's service and will definitely order from you again.
NEXIUM is indicated for the short-term treatment (4 to 8 weeks) in the
healing and symptomatic resolution of diagnostically confirmed erosive
esophagitis. For those patients who have not healed after 4–8 weeks of
treatment, an additional 4–8-week course of NEXIUM may be considered.
Maintenance of Healing of Erosive Esophagitis.
NEXIUM is indicated to maintain symptom resolution and healing
of erosive esophagitis. Controlled studies do not extend beyond
6 months.
NEXIUM is indicated for treatment of heartburn and other symptoms
associated with GERD.
Symptomatic response to therapy with NEXIUM does not preclude the
presence of gastric malignancy.
Atrophic gastritis has been noted occasionally in gastric corpus biopsies
from patients treated long-term with omeprazole, of which NEXIUM is an
enantiomer.
Ingredients
The active ingredient in NEXIUM (esomeprazole magnesium)
is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-
dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-1-yl) magnesium
trihydrate, a compound that inhibits gastric acid secretion.
Esomeprazole is the S-isomer of omeprazole, which is a mixture of the
S- and R-isomers. Its empirical formula is (C17H18N3O3S)2Mg x 3 H2O
with molecular weight of 767.2 as a trihydrate and 713.1 on an anhydrous
basis.
The magnesium salt is a white to slightly colored crystalline powder. It
contains 3 moles of water of solvation and is slightly soluble in water.
The stability of esomeprazole magnesium is a function of pH; it rapidly
degrades in acidic media, but it has acceptable stability under alkaline
conditions. At pH 6.8 (buffer), the half-life of the magnesium salt is about
19 hours at 25°C and about 8 hours at 37°C.
